As far as the guitar part this song is exactly two chords, and it's freakin awesome.
I went into a pretty detailed description of the tuning in my
Bwomp tap. Slightly less than a quarter step down from C. But it doesn't
really matter what tuning you play this in as long as the chords you're
hitting are E and D (a quarter step down of course!)
First and last riff
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|-6-6-----6-6-----6-6-----6--------|
|-4-4-----4-4-----4-4-----4--------|
[ Tab from: http://www.guitaretab.com/m/mushroomhead/337897.html ]
Then it reverses...
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|-----6-6-----6-6-----6-6-----6-6--|
|-----4-4-----4-4-----4-4-----4-4--|
Chorus
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|-4---------------4----------------|
|-2---------------2----------------|
Verse (Look familier?)
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|-6-6-----6-6-----6-6-----6--------|
|-4-4-----4-4-----4-4-----4--------|