the whole song is basically one riff:
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----------0-2--------------|
--------3-----3-0----------|
[ Tab from: http://www.guitaretab.com/j/john-lee-hooker/279551.html ]
what i like to do is make it more exciting
by adding more drama
so when he gets to the part where he says h'es gonna take by the river I add
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----0-2-------x-x--x-x-----0-2-------x-x--x-x-|
--3-----3-0---x-x--x-x---3-----3-0---x-x--x-x-|
then to add more suspense i throw in an Eb chord
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----0-2-------2-2--2-2-----0-2-------2-2--2-2-|
--3-----3-0---0-0--0-0---3-----3-0---0-0--0-0-|